BIOL 304 6380 Explain in your own words why cancer is so hard to cure even with all of our modern biotechnology

BIOL 304 6380 Explain in your own words why cancer is so hard to cure even with all of our modern biotechnology

BIOL 304 6380 Explain in your own words why cancer is so hard to cure even with all of our modern biotechnology

With modern biotechnology, several non-curative treatment options for different types of cancer have been discovered including radiotherapy and chemotherapy (Yahya & Alqadhi, 2021). However, it is important to note that with the complex development of different types of cancer, no cure has been found. Even for the non-curative treatment options, several negative consequences have been reported such as damage to surrounding tissues, furthering wound complications, and damaging red blood cells (Adam et al., 2022). Consequently, these treatment options are unable to kill all the cancer cells in a given area (Hansen & Read, 2020). As such, the resistant cancer cell will end up dividing and spreading into other areas, which may require a different treatment option (Schade et al., 2022). As such, it is crucial to develop a targeted therapeutic option as a cure, but very unlikely as a result of the different key biological factors around cancerous cell growth.

What are some problems that scientists would need to solve to eradicate all types of cancers?

            All cancer cells vary in different perspectives. This heterogeneity in cancer cells makes it hard for scientists to

BIOL 304 6380 Explain in your own words why cancer is so hard to cure even with all of our modern biotechnology
BIOL 304 6380 Explain in your own words why cancer is so hard to cure even with all of our modern biotechnology

develop a single treatment that can eliminate all types of cancer. The heterogeneity is mainly a result of factors associated with uncontrolled division and rapid growth of cancer cells (Hansen & Read, 2020). As such, a cancer cell that a patient may have now may be different from the one the same patient will have a month later. Even with the presence of modern sequencing methodologies and proper analytics to predict and track the changes in cancer cells as they rapidly divide, a scientist will still find it hard to hit a target that is moving as compared to that which is static (Adam et al., 2022). A good example is a drug that is developed as a gene BCL2L1 inhibitor in gastric cancer cells, to enable them to undergo cellular death or apoptosis, which may not work for a different type of cancer (Schade et al., 2022).

Do you predict that we will have a cure for cancer in the next 50 years?  Why or why not?

The search for a cure for cancer is challenging but not hopeless. With the current innovation in oncology by scientists new potential treatment modalities have been discovered, from immunotherapies and molecule therapies that target particular mutations in tumor DNA, to modifying viruses genetically and delivering cancer-fighting agents into the tumor (NCI Staff, 2020). I believe that this is not the end of the fight, and a cure for specific types of cancer may be discovered within the following 50 years.

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References

Adam, R., Badrudin, D., Allard, M. A., Golse, N., Ulusakarya, A., Cherqui, D., Sa Cunha, A., Vibert, E., Azoulay, D., Ciacio, O., Pittau, G., Lucchese, A., Hammel, P., Lewin, M., & Giacchetti, S. (2022). Is cure possible for breast cancer metastatic to the liver? Journal of Clinical Oncology40(16_suppl), 1099–1099. https://doi.org/10.1200/jco.2022.40.16_suppl.1099

Hansen, E., & Read, A. F. (2020). Cancer Therapy: Attempt to cure or manage drug resistance? Evolutionary Applications13(7), 1660–1672. https://doi.org/10.1111/eva.12994

NCI Staff. (2020, July 27). How CRISPR Is Changing Cancer Research and Treatment – National Cancer Institute. Www.cancer.gov. https://www.cancer.gov/news-events/cancer-currents-blog/2020/crispr-cancer-research-treatment

Schade, S., Koenig, U., Mekolli, A., Gaedcke, J., Neesse, A., Reinecke, J., Brunner, M., Hosseini, A. S. A., Kitz, J., Stroebel, P., Lotz, J., Ghadimi, M., Ellenrieder, V., & Koenig, A. (2022). Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab. Case Reports in Gastroenterology16, 80–88. https://doi.org/10.1159/000520057

Yahya, E. B., & Alqadhi, A. M. (2021). Recent trends in cancer therapy: A review on the current state of gene delivery. Life Sciences269, 119087. https://doi.org/10.1016/j.lfs.2021.119087