NUR 550 Consider ecological and global issues, social determinants of health, principles of genetics, and genomics

NUR 550 Consider ecological and global issues, social determinants of health, principles of genetics, and genomics

NUR 550 Consider ecological and global issues, social determinants of health, principles of genetics, and genomics

Translational researcher bridges the gap between basic science and clinical practice, which can help to address the burden of global disease by providing practical solutions to some of the most pressing health problems in many communities globally. It can be applied to ecological and global issues, social determinants of health, principles of genetics, and genomics to address the burden of global disease.

Ecological and global issues such as climate change and environmental degradation significantly impact global health, with rising temperatures increasing the incidence of infectious diseases, air pollution causing respiratory problems, and water scarcity spreading water-borne diseases and occupational exposures (Shaffer et al., 2019). Understanding what promotes healthy and unhealthy behaviors in a community can help design better and more targeted interventions to improve health outcomes (Mensah & Czajkowski, 2018). With translational research, we can investigate the links between environmental factors and disease and to develop strategies for preventing and treating diseases caused by exposure to environmental factors. causes of health disparities worldwide and develop solutions to mitigate these effects. Genomic knowledge helps to enhance the understanding of why some people stay healthy while others are more predisposed to illness due to genetic variations (National Health Services, 2022). Translational research helps to improve the knowledge of how the genome impacts the etiology and risk of diseases which helps to improve the understanding of how diseases can be prevented. Genetic and genomic advances have resulted in a better understanding of the genetic basis of many diseases, including cancer, heart disease, and neurological disorders. Translational researchers can now identify the genetic causes of many diseases due to the advances in gene sequencing technologies and use the knowledge to create new diagnostic tools, treatments, and preventive measures.

 

References

 

Mensah, G. A., & Czajkowski, S. M. (2018). Translational science matters: forging partnerships between biomedical and behavioral science to advance the public’s health. Translational Behavioral Medicine8(5), 808-814. https://academic.oup.com/tbm/article-abstract/8/5/808/4956152

 

National Health Services. (2022). Accelerating genomic medicine in the NHS. https://www.england.nhs.uk/long-read/accelerating-genomic-medicine-in-the-nhs/

 

Shaffer, R. M., Sellers, S. P., Baker, M. G., de Buen Kalman, R., Frostad, J., Suter, M. K., … & Hu, H. (2019). Improving and expanding estimates of the global burden of disease due to environmental health risk factors. Environmental Health Perspectives127(10), 105001. https://ehp.niehs.nih.gov/doi/abs/10.1289/EHP5496

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Disease prevention and health promotion depends heavily on human behaviors throughout a person’s lifetime (Mensah & Czajkowski, 2018). These human behaviors can be influenced by social determinants such as socioeconomic status, education levels, access to and ability to pay for preventative healthcare, and other environmental factors (Mensah & Czajkowski, 2018). While traditional disease prevention and treatment has been focused on implementing evidence-based behavior modifications, this may not always be the best option. For example, a person with a family history of heart disease may be education by their PCP to exercise, eat a healthy diet, and stop smoking. Depending on their socioeconomic status, eating healthy, nutritious food might be a challenge for them. Exercising or having access to a gym might not be something they can afford either, and smoking cessation tools or medications might be out of reach for them as well.  Through translational research, this particular patient and/or population’s behaviors can be studied, along with environmental and social factors, to determine what interventions can be applied to help reduce the changes of developing heart disease, diabetes, or other diseases that their behaviors and lifestyles might contribute to. On a global level, these same principles can be applied to varying populations to aid in disease prevention and treatment. Together with epidemiology, populations can be studied to determine what genetic, environmental, economic, and behavioral factors contribute to and affect the control of disease across different populations (Gilliland, et al., 2016). For example, the population of one country may have genetic predispositions to certain disease process versus other countries, so interventions can be developed and implemented through translational research to help that population prevent disease before it’s even developed.

References:

Gilliland, C. T., Zuk, D., Kocis, P., Johnson, M., Hay, S., Bietrix, F., . . . Ussi, A. E. (2016, April). Putting Translational Science onto a Global Stage. National Reviews Drug Discovery, 15(4), 217-218. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378162/

Mensah, G. A., & Czajkowski, S. M. (2018, March). Translational science matters: forgoing partnerships between biomedical and behavioral science to advance the public’s health. Translational Behavioral Medicine, 8(5), 808-814. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454531/

Ecological and global issues, social determinants of health, and principles of genetics as well as genomics impact the delivery of healthcare and influence the burden of global diseases like the COVID-19 pandemic. Translational research entails the transfer of research knowledge to healthcare settings, especially public health, to improve population health. Translational research is applicable to ecological and global issues, social determinants of health, principles of genetics and genomics. The rationale behind translational research is the use of new scientific approaches and innovation and convert them into practice (Garmon, 2019). These innovations become treatment protocols and interventions to offer patents the best care. Clinical research is critical to translation of scientific innovations into treatments that can be impactful to groups of people with the health populations. For instance, genetics entails study of the genetic formation within a certain families and their genetic makeup that can help researchers discover disease patterns in such individuals and develop treatment interventions through clinical research. Public health presentation of genomics concentrates on the occurrence of rare disease like those discovered through the screening of newborns. Imperatively, much of the future of genomics rests on its use to understand common conditions.

The global healthcare system relies on medical and translational research that integrates useful and relevant

NUR 550 Consider ecological and global issues, social determinants of health, principles of genetics, and genomics
NUR 550 Consider ecological and global issues, social determinants of health, principles of genetics, and genomics

outcomes which assists in enhancing public health through rapid scientific discoveries, sophisticated healthcare delivery, and inter-professional collaboration. These efforts also include public outreach programs, support for medical and health practices (Rubio et al., 2019). Translational ecology brings together researchers and environmentalists to develop solutions on different aspects of the environment that can impact health, especially public health.

Through the analysis of social determinants of health, translational studies can improve the healthcare system. for instance, to attain a healthy population, it is essential to have socioeconomic progress, social support systems and networks, and an affordable healthcare system that leads to increased accessibility (Molster et al., 2018). Evidence from community-based translational research can help stakeholders engage with and implement programs to improve accessibility and prevention of diseases in community settings.

 

References

Garmon, B. S. C. (2019). Population health. In J. Fitzpatrick (Ed.), Encyclopedia of nursing

research (4th ed.). Springer Publishing Company.

Molster, C. M., Bowman, F. L., Bilkey, G. A., Cho, A. S., Burns, B. L., Nowak, K. J., &

Dawkins, H. J. (2018). The evolution of public health genomics: exploring its past, present, and future. Frontiers in public health, 6, 247. https://doi.org/10.3389/fpubh.2018.00247

Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., …

& Bermejo-Martín, J. F. (2019). Current gaps in sepsis immunology: new opportunities for translational research. The Lancet Infectious Diseases, 19(12), e422-e436. doi: 10.1016/S1473-3099(19)30567-5.