NUR 550 Discuss the ethical guidelines that would need to be implemented when conducting translational research

NUR 550 Discuss the ethical guidelines that would need to be implemented when conducting translational research

NUR 550 Discuss the ethical guidelines that would need to be implemented when conducting translational research

As with any research or experiments conducted on the human body, translational research and studies can pose many ethical concerns that one should be aware of before implementation. Ensuring informed consent is the responsibility of any researcher, especially those in the T1 and T2 phase of translational research studies (Mandal, Ponnambath, & Parija, 2017) Legal implications may even arise if participants are not well informed of the process and all the risks/benefits that may exist.  By ensuring patients are giving their completely informed consent, researchers can eliminate any misconceptions participants may have about the therapeutic benefits of the study that may lead them to participate when they might not have otherwise (Mandal, Ponnambath, & Parija, 2017). Conflicts of interest are another ethical concern in translational research, especially if researchers have anything to gain financially from the study. Social injustice is another ethical concern, especially dealing with population health issues. One example of this might be a resource-rich country conducting a study in a resource-poor country, but the benefits to the health of the population in the resource-poor country might be minimal, or products being studied might be too expensive for participants or the rest of the population to even be able to afford after the study has concluded (Mandal, Ponnambath, & Parija, 2017). This is one area I think it’s important to be mindful of as researchers design studies and where to conduct them. If I were to design a research study and assemble a team, I would ensure that the study was conducted with the goal of improving a problem that is a burden to the health of the population included in the study, and that the interventions or products being developed would actually be affordable to those within that population. I feel this approach would be best to help improve the health of the population in the study.

References:

Mandal, J., Ponnambath, D., & Parija, S. (2017). Ethics of translational medical research. Tropical Parasitilogy, 7(2), 62-64. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652056/

The ethical challenges faced by translational research depend on the element of the translational process. The various phases of translational research face ethical issues like the biomedical research ethics such as informed consent, animal bioethics, conflicts of interest, social injustice, and risk analysis ethics. The translational gaps confront ethical issues of resource/fund allocation whereas data/information transfer suffer ethical issues with confidentiality of data. (Mandal,et.al 2017) .

Ethical guidelines would need to be implemented when conducting translational research. These ethical guidelines

NUR 550 Discuss the ethical guidelines that would need to be implemented when conducting translational research
NUR 550 Discuss the ethical guidelines that would need to be implemented when conducting translational research

should be interesting for research that is more open to social needs, but also for preventing malpractice. In training and career, researchers could benefit from these principles. The researcher should consider 1) Justice, equality, and quality,2) Autonomy and social relevance 3) Responsibility. Researcher should cultivate an environment in which ethics is seen as a positive and integral part of performing research. (López de la Vieja, 2016).

As a member of a translational research team, I would make the ethical framework seem relevant for a consistent decision making, notably when the allocation of resources and the assessment of health care are at stake. Requirements such as patients’ needs, including competing needs, fairness, non-discrimination which will create equal chances or equal consideration of them. In general, the research policy must be accountable, and it should integrate the gender perspective, to avoid biases. So, this strategy seems consistent with the legislation concerning research, with ethical principles and governance principles. The integration of research and practices – to bridge real gaps – will require efficiency and additional criteria; for example, it should become more reflexive about possible outcomes, promoting the dialogue with society – as multi-actor exchanges and then, being responsive to agents’ needs. In this sense, responsibility and, in general, ethical principles add value to a model of science connected with public interests (López de la Vieja, 2016).

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Professional communities should also promote the adoption of standards that lead to ethical conduct, because even physicians themselves might be at risk of serious bias or conflict of interest. An integrated ethical approach that aims for transparency and regulation of development processes, the support of independent judgment and the elimination of unregulated and uncontrolled grey areas of action are necessary (Riva; et al,2019).

References:

 

Mandal, J., Ponnambath, D. K., & Parija, S. C. (2017). Ethics of translational medical research. Tropical parasitology7(2), 62–64. https://doi.org/10.4103/tp.TP_47_17

 

López de la Vieja, M. T. (2016). Ethics and governance in translational research. Ethics, Medicine and Public Health2(2), 256–262. https://doi-org.lopes.idm.oclc.org/10.1016/j.jemep.2016.04.002

 

Riva, L., & Petrini, C. (2019). A few ethical issues in translational research for gene and cell therapy. Journal of Translational Medicine17(1), N.PAG. https://doi-org.lopes.idm.oclc.org/10.1186/s12967-019-02154-5

All healthcare providers must act in an ethical manner.  Ethics should be at the core of everything we do and be a part of every decision that we make while keeping in mind the best interests of the patient (DeNisco, 2021).  Ethics in translational research can be tricky due to the nature of what is being researched.  Translational research is research that studies how evidence-based interventions are translated to real-world clinical settings (Melnyk, 2019).  However, to bring that research into the real-world multiple phases of testing must take place.  At any point during the different phases of translational research, harm can be done to either animals or humans.  This is where ethics in translational research can become tricky.

While the intent of any translational research study is to have a good outcome that is not always the case.  The researchers must weigh the risks and benefits to the study participants versus the risks and benefits to the greater good of all people.  Legal and ethical guidelines are standard practice for all research studies and must be followed by all team members.  I think that as part of a translational research team the most important thing to ensure that all team members are following the proper protocols, and legal and ethical guidelines.

 

References

 

DeNisco, S. M. (Ed.). (2021). Advanced practice nursing: Essential knowledge for the profession (4th ed.). Jones & Bartlett Learning. ISBN-13: 978128417612

 

Melnyk, B. M., & Fineout-Overholt, E. (2019). Evidence-based practice in nursing and healthcare: A guide to best practice (4th ed.). Wolters Kluwer. ISBN-13: 9781496384539

Great Post about ethical considerations. Ethics can be hard because you have to be sure to put your own bias opinions aside and do what the patient wants and what’s in the best interest of the individuals. You stated it correctly, that all team members need to follow all protocols properly and make sure all guidelines are being followed to prevent a breach in ethical decisions.

Ethics in the research team are important for many reasons. First, it can promote the goal of research with their knowledge, truth, and avoids error (Resnik, 2022). Second, being ethical allows for better overall collaboration. This allows for the team to have trust, accountability, and fairness (Rasnik, 2022). Next, it builds trust of the community. Fourth, ethics can assist in building the support of the public and finally ethics is important for social moral and values (Resnik, 2022).

 

Resnik, D. (2022). What is ethics in research and why is it important? National institute of Environmental Health Sciences. https://www.niehs.nih.gov/research/resources/bioethics/whatis/index.cfm#:~:text=There%20are%20several%20reasons%20why,the%20truth%20and%20minimize%20error.