NUR 550 Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research

NUR 550 Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research

NUR 550 Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research

Re: Topic 1 DQ 2

When looking through the GCU library for an interesting study containing translational research, I found this study called “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” (Harischandra et. Al, 2020). This study states that there are treatment options out there for those patients with Parkinsons, like deep brain stimulation and medications like levodopa, but these treatments are only touching the surface of the issue at hand (Harischandra et. Al, 2020). They state that for future (better) treatment for these patients they need to look at the dopaminergic neurons as well as the dopamine transporter (Harischandra, et. Al, 2020). They attempted to preform studies on rats but found that the cells differed in a way that would not give them accurate results (Harishchandra, et. Al, 2020). They then went on to utilize embryonic stem cells and developing these into LUHMES cells which more closely resembled the pathways they were trying to achieve (Harischandra, et. Al, 2020). By doing their experiments on these cells they are in the T1 transition, pre patient and practice, in the lab studying the real effects on the neural pathways (Translational Research, n.d.). I’m not going to lie the study is lengthy and the process they utilized involved a ton of chemicals and days of watching these cells develop into what they needed, but at the end of 5 days their processes had drastically increased the reuptake of dopamine in the cells (Hasichandra, et. Al, 2020). Stem Cells are not always available for drug research so being able to develop these LUHMES cells to test on is great for the future of Parkinsons research and for testing drugs (Harischandra et. Al, 2020).

Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533

Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions

 

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Re: Topic 1 DQ 2

Incidences of stroke in the U.S. have declined in the past few years for the first time in history. However, stroke incidence among older adults has always been higher than younger adults, especially older women (Portz et al., 2018). Older adults of 80 years and above make about 17% of all stroke patients and are at high risk of mortality and prolonged hospital stays (Portz et al., 2018). This journal is in phase T4 type of translational research, where the information obtained in the previous stages is disseminated and implemented. This translational research aimed to investigate the impact of physical fitness and exercises for older adults with chronic stroke. A large body of literature has examined the correlation between self-management intervention such as physical fitness and exercise and chronic stroke. For instance, Schmid et al. (2014) observed that patients with chronic stroke showed physical improvements like body balance after enrolling in a yoga program that involved physical activities such as walking.

Based on the previous literature, Portz et al. (2018) used the information to investigate whether physical fitness and

NUR 550 Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
NUR 550 Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research

exercise would be used as a clinical intervention for managing chronic stroke. After implementing the information, Portz et al. (2018) found that it is essential for health care professionals to incorporate self-management interventions such as physical fitness and exercise in managing chronic stroke among older adults. This will improve their quality of life, strength, and endurance by incorporating yoga practice. Furthermore, this kind of research will encourage more health care researchers to conduct translational research to reach phase 4 (T4), where yoga practice can be used as an evidence-based intervention for chronic stroke.

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References

Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453

Schmid, A. A., Miller, K. K., Van Puymbroeck, M., & DeBaun-Sprague, E. (2014). Yoga leads to multiple physical improvements after stroke, a pilot study. Complementary Therapies in Medicine, 22(6), 994–1000. https://doiorg.lopes.idm.oclc.org10.1016/j.ctim.2014.09.005

 

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Re: Topic 1 DQ 2

Medicinal marijuana has been a growing interest and in fact, there are currently 36 states in the country that have laws making medical marijuana legal as of May 2021 (National Conference of State Legislatures [NCSL], 2021) The reason for that is because there have been numerous studies proving the health benefit from use for chronic pain, nausea, appetite stimulant and many other health concerns. The article I selected is a study looking at medical marijuana use in pediatric oncology patients.

This study consisted of 50 pediatric oncology patients who were prescribed medical marijuana for a variety of symptoms. They assessed patient and parent reported outcomes of pain, appetite, sleep, nausea and vomiting, mood, and other side effects. Side effects and safety was monitored and documented from the medical marijuana use. The results of this study showed that medical marijuana can potentially be useful in side effect management in the pediatric oncology population. Due to the low sample size, future studies are needed to truly assess the safety, efficacy and proper dosing of medical marijuana in the pediatric population (Ofir et al., 2019).

This study would be considered part of the T1 translational research looking at proof of concept by using a small sample size (Titler, 2018). It is important to always start out with a small sample size to ensure patient safety. Many would be concerned about the adverse effects of medicinal marijuana in the pediatric population, so it is important to show several translational research studies before implementing it into the general practice.

References

National Conference of State Legislatures. (2021, June 9). State Medical Marijuana Laws [Press release]. https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx

Ofir, R., Bar-Sela, G., Weyl Ben-Arush, M., & Postovsky, S. (2019). Medical marijuana use for pediatric oncology patients: Single institution experience. Pediatric Hematology and Oncology36(5), 255–266. https://doi.org/10.1080/08880018.2019.1630537

Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing23(2). https://doi.org/10.3912/OJIN.Vol23No02Man01